FADD anticorps (C-Term) (PE)

N° du produit ABIN7989703

L’anticorps anti-FADD Polyclonal Lapin est utilisé pour la détection de FADD dans des échantillons de Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour FADD anticorps (C-Term) (PE) (ABIN7989703)

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FADD est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-FADD anticorps (PE)

Épitope: C-Term

Fonction: Anti-FADD Antibody PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of rat FADD, which shares 66.7% and 81.8% amino acid (aa) sequence identity with human and rat FADD, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur FADD

Antigène: FADD (Fas (TNFRSF6)-Associated Via Death Domain (FADD))

Autre désignation: Fadd

Sujet:

Background: FADD, Fas-Associated protein with Death Domain, is a universal adaptor protein in apoptosis that mediates signaling of all known death domain-containing members of the TNF receptor superfamily. The FADD gene contains 2 exons and spans approximately 3.6 kb. By analysis of somatic cell hybrid panels and by fluorescence in situ hybridization, the FADD gene is mapped to 11q13.3. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, thus, it participates in the death signaling initiated by these receptors.

Gene Full Name: Fas associated via death domain

ID gène: 266610

UniProt: Q8R2E7

Pathways: Apoptose, Signalisation TLR, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades