FRZB anticorps (AA 176-325) (HRP)

N° du produit ABIN7991896

L’anticorps anti-FRZB Polyclonal Lapin est utilisé pour la détection de FRZB dans des échantillons de Humain. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour FRZB anticorps (AA 176-325) (HRP) (ABIN7991896)

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FRZB est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FRZB anticorps (HRP)

Épitope: AA 176-325

Fonction: Anti-FRZB Antibody HRP Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur FRZB

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Autre désignation: FRZB

Sujet:

Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.

Gene Full Name: frizzled related protein

Sequence Similarities: Belongs to the secreted frizzled-related protein (sFRP) family.

ID gène: 2487

UniProt: Q92765

Pathways: Signalisation WNT, Positive Regulation of fat Cell Differentiation