GDF15 anticorps (AA 51-199) (HRP)

N° du produit ABIN7995312

Cet anticorps Lapin Polyclonal détecte spécifiquement GDF15 dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour GDF15 anticorps (AA 51-199) (HRP) (ABIN7995312)

Antigène: GDF15 (Growth Differentiation Factor 15 (GDF15))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GDF15 est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-GDF15 anticorps (HRP)

Épitope: AA 51-199

Fonction: Anti-PDF Antibody HRP Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human PDF shares 82.4% amino acid (aa) sequence identity with mouse PDF.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PDF recombinant protein (Position: H51-Q199). Human PDF shares 82.4% amino acid (aa) sequence identity with mouse PDF.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur GDF15

Antigène: GDF15 (Growth Differentiation Factor 15 (GDF15))

Autre désignation: PDF

Sujet:

Background: Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.

Gene Full Name: peptide deformylase, mitochondrial

ID gène: 64146

UniProt: Q9HBH1

Pathways: SARS-CoV-2 Protein Interactome