INPP5D anticorps (AA 81-1093) (Fluoro488)

N° du produit ABIN7999759

Cet anticorps anti-INPP5D Polyclonal Lapin conjugué à Fluoro488 (ABIN7999759) détecte spécifiquement INPP5D dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour INPP5D anticorps (AA 81-1093) (Fluoro488) (ABIN7999759)

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INPP5D est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-INPP5D anticorps (Fluoro488)

Épitope: AA 81-1093

Fonction: Anti-INPP5D Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Human INPP5D shares 87.6%,87.5% amino acid (aa) sequence identity with mouse,rat INPP5D,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human INPP5D recombinant protein (Position: Q81-E1093). Human INPP5D shares 87.6% and 87.5% amino acid (aa) sequence identity with mouse and rat INPP5D, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur INPP5D

Antigène: INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))

Autre désignation: INPP5D

Sujet:

Background: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 is an enzyme that in humans is encoded by the INPP5D gene. This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.

Gene Full Name: inositol polyphosphate-5-phosphatase D

ID gène: 3635

UniProt: Q92835

Pathways: TCR Signaling, BCR Signaling, L'effet Warburg