INSIG1 anticorps (AA 1-87)

N° du produit ABIN7999833

L’anticorps anti-INSIG1 Polyclonal Lapin est utilisé pour la détection de INSIG1 dans des échantillons de Humain. Il a été validé pour WB, ELISA, FACS, IHC, IF et ICC.

Aperçu rapide pour INSIG1 anticorps (AA 1-87) (ABIN7999833)

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSIG1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Classe de qualité: Carrier-free

Détail du produit anti-INSIG1 anticorps

Épitope: AA 1-87

Fonction: Anti-INSIG1 Antibody

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Anti-INSIG1 Antibody. Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human INSIG1 recombinant protein (Position: M1-R87).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur INSIG1

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Autre désignation: INSIG1

Sujet:

Background: Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene. This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.

Gene Full Name: insulin induced gene 1

Poids moléculaire: 66 kDa

ID gène: 3638

UniProt: O15503

Pathways: ER-Nucleus Signaling