IDE anticorps (AA 485-756) (FITC)

N° du produit ABIN7999938

L’anticorps anti-IDE Polyclonal Lapin est utilisé pour la détection de IDE dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour IDE anticorps (AA 485-756) (FITC) (ABIN7999938)

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IDE est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-IDE anticorps (FITC)

Épitope: AA 485-756

Fonction: Anti-Insulin degrading enzyme/IDE Antibody FITC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human IDE recombinant protein (Position: F485-K756).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur IDE

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Autre désignation: IDE

Sujet:

Background: Insulin-degrading enzyme, also known as IDE, is an enzyme. This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: insulin degrading enzyme

ID gène: 416

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome