IL21 Receptor anticorps (Middle Region) (PE)

N° du produit ABIN8002329

L’anticorps anti-IL21 Receptor Polyclonal Lapin est utilisé pour la détection de IL21 Receptor dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour IL21 Receptor anticorps (Middle Region) (PE) (ABIN8002329)

Antigène: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL21 Receptor est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Détail du produit anti-IL21 Receptor anticorps (PE)

Épitope: Middle Region

Fonction: Anti-IL21R Antibody PE Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human IL21R. Human IL21R shares 78.6% amino acid (aa) sequence identity with mouse IL21R.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur IL21 Receptor

Antigène: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Autre désignation: IL21R

Sujet:

Background: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

Gene Full Name: interleukin 21 receptor

ID gène: 50615

UniProt: Q9HBE5

Pathways: Signalistation JAK/STAT