LDLR anticorps (AA 705-860) (Fluoro488)

N° du produit ABIN8006549

Cet anticorps Lapin Polyclonal détecte spécifiquement LDLR dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour LDLR anticorps (AA 705-860) (Fluoro488) (ABIN8006549)

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LDLR est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-LDLR anticorps (Fluoro488)

Épitope: AA 705-860

Fonction: Anti-LDLR Antibody Fluoro488 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human LDLR recombinant protein (Position: A705-A860).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur LDLR

Antigène: LDLR (Low Density Lipoprotein Receptor (LDLR))

Autre désignation: LDLR

Sujet:

Background: In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. It is mapped to 19p13.2. The low absorbance lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low absorbance lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Gene Full Name: low density lipoprotein receptor

ID gène: 3949

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism