MMP12 anticorps (AA 237-442) (HRP)

N° du produit ABIN8008061

Cet anticorps Lapin Polyclonal détecte spécifiquement MMP12 dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour MMP12 anticorps (AA 237-442) (HRP) (ABIN8008061)

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP12 est conjugé à/à la HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-MMP12 anticorps (HRP)

Épitope: AA 237-442

Fonction: Anti-Mmp12 Antibody HRP Conjugated

Réactivité croisée (Details): No cross reactivity with other proteins.

Homologie: Mouse Mmp12 shares 62.7%,90.3% amino acid (aa) sequence identity with mouse,rat Mmp12,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Mmp12 recombinant protein (Position: K237-H442). Mouse Mmp12 shares 62.7% and 90.3% amino acid (aa) sequence identity with mouse and rat Mmp12, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur MMP12

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Autre désignation: Mmp12

Sujet:

Background: Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene. This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms.

Gene Full Name: matrix metallopeptidase 12

ID gène: 17381

UniProt: P34960