MAG anticorps (AA 34-605) (Fluoro647)

N° du produit ABIN8012355

L’anticorps anti-MAG Monoclonal Souris est utilisé pour la détection de MAG dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour MAG anticorps (AA 34-605) (Fluoro647) (ABIN8012355)

Antigène: MAG (Myelin Associated Glycoprotein (MAG))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAG est conjugé à/à la Fluoro647

Application: Flow Cytometry (FACS)

Clone: 2G11

Détail du produit anti-MAG anticorps (Fluoro647)

Épitope: AA 34-605

Fonction: Anti-MAG Antibody (monoclonal, 2G11) Fluoro647 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human MAG recombinant protein (Position: E34-R605).

Isotype: IgG2a

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur MAG

Antigène: MAG (Myelin Associated Glycoprotein (MAG))

Autre désignation: MAG

Sujet:

Background: MAG (Myelin-associated glycoprotein),also known as SIGLEC4A, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is though to be involved in the process of myelination. MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney (HEK) cells expressing the NOGO receptor, p75 (NTR) was required for MAG-induced intracellular calcium elevation.

Gene Full Name: myelin associated glycoprotein

ID gène: 4099

UniProt: P20916

Pathways: Neurotrophin Signaling Pathway