FcRn anticorps (AA 56-291) (Biotin)

N° du produit ABIN8014218

L’anticorps anti-FcRn Polyclonal Lapin est utilisé pour la détection de FcRn dans des échantillons de Humain. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour FcRn anticorps (AA 56-291) (Biotin) (ABIN8014218)

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FcRn est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FcRn anticorps (Biotin)

Épitope: AA 56-291

Fonction: Anti-FCGRT Antibody Biotin Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: coli-derived human FCGRT recombinant protein (Position: Q56-E291). Human FCGRT shares 70.2%,68.9% amino acid (aa) sequence identity with mouse,rat FCGRT,respectively.

Purification: Immunogen affinity purified.

Immunogène: E. coli-derived human FCGRT recombinant protein (Position: Q56-E291). Human FCGRT shares 70.2% and 68.9% amino acid (aa) sequence identity with mouse and rat FCGRT, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur FcRn

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Autre désignation: FCGRT

Sujet:

Background: IgG receptor FcRn large subunit p51?is a?protein?that in humans is encoded by the?FCGRT?gene. This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation.?In addition, it is postulated that long-range cis inactivation of the?FCGRT?gene is responsible for hypercatabolism of IgG in myotonic dystrophy. The?FCGRT?gene is closely situated to the DMPK gene, which is mutant in DM.?

Gene Full Name: Fc gamma receptor and transporter

ID gène: 2217

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process