PRKACG anticorps (AA 251-351)

N° du produit ABIN751813

Cet anticorps Lapin Polyclonal détecte spécifiquement PRKACG dans WB, IF (cc), IF (p), IHC (p) et IHC (fro). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PRKACG anticorps (AA 251-351) (ABIN751813)

Antigène: PRKACG (Protein Kinase, CAMP-Dependent, Catalytic, gamma (PRKACG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKACG est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PRKACG anticorps

Épitope: AA 251-351

Fonction: PKA gamma Polyclonal Antibody

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PKA gamma

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000),

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PRKACG

Antigène: PRKACG (Protein Kinase, CAMP-Dependent, Catalytic, gamma (PRKACG))

Autre désignation: PKA gamma

Sujet:

Synonyms: KAPG, PKA C gamma, PRKACG, Protein kinase cAMP dependent catalytic gamma, Serine threonine protein kinase, KAPCG_HUMAN.

Background: PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.

ID gène: 5568

Pathways: AMPK Signaling, Signalisation Hedgehog, Thyroid Hormone Synthesis, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Lipid Metabolism