Nibrin anticorps (C-Term)

N° du produit ABIN8015427

L’anticorps anti-Nibrin Monoclonal Souris est utilisé pour la détection de Nibrin dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, IHC, IF, ICC et FACS.

Aperçu rapide pour Nibrin anticorps (C-Term) (ABIN8015427)

Antigène: Nibrin (NBN)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Nibrin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: 5D7A1

Détail du produit anti-Nibrin anticorps

Épitope: C-Term

Fonction: Anti-p95 NBS1 Antibody (monoclonal, 5D7A1)

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by three amino acids,and from the related rat sequence by five amino acids.

Attributs du produit: Anti-p95 NBS1 Antibody.(monoclonal, 5D7A1)-1. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human p95 NBS1, different from the related mouse sequence by three amino acids, and from the related rat sequence by five amino acids.

Isotype: IgG2a

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x⁶ cells, Human

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur Nibrin

Antigène: Nibrin (NBN)

Autre désignation: NBN

Sujet:

Background: p95 NBS1, also known as NBN or Nibrin, is a protein which in humans is encoded by the NBN gene. Nibrin is a protein associated with the repair of double strand breaks (DSBs) which pose serious damage to a genome. It is a 754 amino acid protein identified as a member of the NBS1/hMre11/RAD50(N/M/R, more commonly referred to asMRN) double strand DNA break repair complex. This complex recognizes DNA damage and rapidly relocates to DSB sites and forms nuclear foci. It also has a role in regulation of N/M/R (MRN) protein complex activity which includes end-processing of both physiological and mutagenic DNA double strand breaks (DSBs).

Gene Full Name: nibrin

Poids moléculaire: 95 kDa

ID gène: 4683

UniProt: O60934

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response