Nicastrin anticorps (N-Term) (APC)

N° du produit ABIN8015457

L’anticorps anti-Nicastrin Polyclonal Lapin est utilisé pour la détection de Nicastrin dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour Nicastrin anticorps (N-Term) (APC) (ABIN8015457)

Antigène: Nicastrin (NCSTN)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nicastrin est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-Nicastrin anticorps (APC)

Épitope: N-Term

Fonction: Anti-Nicastrin/NCSTN Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: different from the related mouse sequence by one amino acid,and from the related rat sequence by two amino acids.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human Nicastrin, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Nicastrin

Antigène: Nicastrin (NCSTN)

Autre désignation: NCSTN

Sujet:

Background: Nicastrin, also known as?NCSTN, is a?protein?that is a part of the gamma secretase?protein complex. It is mapped to 1q23.2. This gene is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the gamma secretase?protein complex, all of which undergo significant post-translational modification?before becoming active in the cell. NCSTN encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex.?The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly.?The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease. Nicastrin has also been identified as a regulator of neprilysin, an?enzyme?involved in the degradation of amyloid beta fragment.

Gene Full Name: nicastrin

Sequence Similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.

ID gène: 23385

UniProt: Q92542

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway