OAZ1 anticorps (N-Term) (Cy3)

N° du produit ABIN8018448

L’anticorps anti-OAZ1 Polyclonal Lapin est utilisé pour la détection de OAZ1 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour OAZ1 anticorps (N-Term) (Cy3) (ABIN8018448)

Antigène: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OAZ1 est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Détail du produit anti-OAZ1 anticorps (Cy3)

Épitope: N-Term

Fonction: Anti-OAZ1 Antibody Cy3 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human OAZ1 shares 100% amino acid (aa) sequence identity with both mouse,rat OAZ1.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human OAZ1. Human OAZ1 shares 100% amino acid (aa) sequence identity with both mouse and rat OAZ1.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur OAZ1

Antigène: OAZ1 (Ornithine Decarboxylase Antizyme 1 (OAZ1))

Autre désignation: OAZ1

Sujet:

Background: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis, thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene.

Gene Full Name: ornithine decarboxylase antizyme 1

ID gène: 4946

UniProt: P54368