Peroxiredoxin 1 anticorps (Middle Region) (APC)

N° du produit ABIN8020590

L’anticorps anti-Peroxiredoxin 1 Polyclonal Lapin est utilisé pour la détection de Peroxiredoxin 1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour Peroxiredoxin 1 anticorps (Middle Region) (APC) (ABIN8020590)

Antigène: Peroxiredoxin 1 (PRDX1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Peroxiredoxin 1 est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-Peroxiredoxin 1 anticorps (APC)

Épitope: Middle Region

Fonction: Anti-Peroxiredoxin 1/PRDX1 Antibody APC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse sequence by one amino acid,and identical to the related rat sequence.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human Peroxiredoxin 1, different from the related mouse sequence by one amino acid, and identical to the related rat sequence.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Peroxiredoxin 1

Antigène: Peroxiredoxin 1 (PRDX1)

Autre désignation: PRDX1

Sujet:

Background: PRDX1 (Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted ly with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein may have a proliferative effect and play a role in cancer development or progression. In differentiating spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2 for the induction of motor neuron differentiation.

Gene Full Name: peroxiredoxin 1

Sequence Similarities: Belongs to the AhpC/TSA family.

ID gène: 5052

UniProt: Q06830

Pathways: Signalisation p53, EGFR Signaling Pathway, CXCR4-mediated Signaling Events