Phospholamban anticorps (N-Term) (Cy3)

N° du produit ABIN8021935

Cet anticorps anti-Phospholamban Polyclonal Lapin conjugué à Cy3 (ABIN8021935) détecte spécifiquement Phospholamban dans FACS. L’anticorps est réactif avec des échantillons de Rat et Souris.

Aperçu rapide pour Phospholamban anticorps (N-Term) (Cy3) (ABIN8021935)

Antigène: Phospholamban (PLN)

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholamban est conjugé à/à la Cy3

Application: Flow Cytometry (FACS)

Détail du produit anti-Phospholamban anticorps (Cy3)

Épitope: N-Term

Fonction: Anti-Phospholamban/PLN Antibody Cy3 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: different from the related mouse,rat sequences by one amino acid.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human PLN, different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Phospholamban

Antigène: Phospholamban (PLN)

Autre désignation: PLN

Sujet:

Background: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. It is observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.

Gene Full Name: phospholamban

Sequence Similarities: Belongs to the phospholipase D family.

ID gène: 5350

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity