Phospholamban anticorps (AA 1-36) (APC)

N° du produit ABIN8021952

L’anticorps anti-Phospholamban Polyclonal Lapin est utilisé pour la détection de Phospholamban dans des échantillons de Humain, Rat et Souris. Il a été validé pour FACS.

Aperçu rapide pour Phospholamban anticorps (AA 1-36) (APC) (ABIN8021952)

Antigène: Phospholamban (PLN)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholamban est conjugé à/à la APC

Application: Flow Cytometry (FACS)

Détail du produit anti-Phospholamban anticorps (APC)

Épitope: AA 1-36

Fonction: Anti-Phospholamban/PLN Antibody APC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Phospholamban/PLN recombinant protein (Position: M1-C36).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur Phospholamban

Antigène: Phospholamban (PLN)

Autre désignation: PLN

Sujet:

Background: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. It is observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.

Gene Full Name: phospholamban

ID gène: 5350

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity