PLCE1 anticorps (AA 4-735) (HRP)

N° du produit ABIN8022175

Cet anticorps anti-PLCE1 Polyclonal Lapin conjugué à HRP (ABIN8022175) détecte spécifiquement PLCE1 dans IHC, WB et ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PLCE1 anticorps (AA 4-735) (HRP) (ABIN8022175)

Antigène: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLCE1 est conjugé à/à la HRP

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA

Détail du produit anti-PLCE1 anticorps (HRP)

Épitope: AA 4-735

Fonction: Anti-PLCE1 Antibody HRP Conjugated

Homologie: Human PLCE1 shares 74.6%,73.6% amino acid (aa) sequence identity with mouse,rat PLCE1,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PLCE1 recombinant protein (Position: E4-E735). Human PLCE1 shares 74.6% and 73.6% amino acid (aa) sequence identity with mouse and rat PLCE1, respectively.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PLCE1

Antigène: PLCE1 (Phospholipase C, epsilon 1 (PLCE1))

Autre désignation: PLCE1

Sujet:

Background: Phospholipase C epsilon 1 (PLCE1) is an enzyme that in humans is encoded by the PLCE1 gene. This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome, characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Full Name: phospholipase C epsilon 1

ID gène: 51196

UniProt: Q9P212

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling