PRKDC anticorps (N-Term) (Fluoro550)

N° du produit ABIN8027713

Cet anticorps anti-PRKDC Polyclonal Lapin conjugué à Fluoro550 (ABIN8027713) détecte spécifiquement PRKDC dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PRKDC anticorps (N-Term) (Fluoro550) (ABIN8027713)

Antigène: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRKDC est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-PRKDC anticorps (Fluoro550)

Épitope: N-Term

Fonction: Anti-DNA PKcs/PRKDC Antibody Fluoro550 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human DNA PKcs.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PRKDC

Antigène: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Autre désignation: PRKDC

Sujet:

Background: PRKDC (Protein Kinase DNA-Activated Catalytic Subunit), also called DNAPK, HYRC1, p350 or DNPK1, is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Satoh et al. (1997) mapped the MCM4 gene to 8q11.2 by FISH. Based on the close proximity of the PRKDC and MCM4 genes, it was assumed that the PRKDC gene also maps to this location. Anderson and Lees-Miller (1992) noted that DNA-PK had been shown in vitro to phosphorylate several transcription factors, suggesting that it functions in cell homeostasis by modulating transcription. Daniel et al. (1999) demonstrated that the PRKDC protein participates in retroviral DNA integration, which is catalyzed by the viral protein integrase.

Gene Full Name: protein kinase, DNA-activated, catalytic subunit

Sequence Similarities: Belongs to the PI3/PI4-kinase family.

ID gène: 5591

UniProt: P78527

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response