PPM1F anticorps (AA 17-454) (FITC)

N° du produit ABIN8027981

Cet anticorps Lapin Polyclonal détecte spécifiquement PPM1F dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PPM1F anticorps (AA 17-454) (FITC) (ABIN8027981)

Antigène: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPM1F est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-PPM1F anticorps (FITC)

Épitope: AA 17-454

Fonction: Anti-PPM1F Antibody FITC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PPM1F recombinant protein (Position: E17-S454).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur PPM1F

Antigène: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Autre désignation: PPM1F

Sujet:

Background: Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1F

ID gène: 9647

UniProt: P49593

Pathways: Positive Regulation of Endopeptidase Activity