RIPK2 anticorps (AA 15-540) (Fluoro550)

N° du produit ABIN8030950

Cet anticorps anti-RIPK2 Polyclonal Lapin conjugué à Fluoro550 (ABIN8030950) détecte spécifiquement RIPK2 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour RIPK2 anticorps (AA 15-540) (Fluoro550) (ABIN8030950)

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RIPK2 est conjugé à/à la Fluoro550

Application: Flow Cytometry (FACS)

Détail du produit anti-RIPK2 anticorps (Fluoro550)

Épitope: AA 15-540

Fonction: Anti-RIP2/RIPK2 Antibody Fluoro550 Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human RIP2/RIPK2 recombinant protein (Position: Y15-M540).

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur RIPK2

Antigène: RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))

Autre désignation: RIPK2

Sujet:

Background: RIPK2(Receptor-interacting serine/threonine-protein kinase 2), also known as CARD3, CARDIAK, RICK, RIP2, is anenzymethat in humans is encoded by theRIPK2gene.It has 540-amino acid protein in length.Northern blot analysis revealed that RICK is expressed in various human tissues as 2.5- and 1.8-kb mRNAs that differ due to alternative polyadenylation. RICK is a novel kinase that may regulate apoptosis induced by the FAS receptor pathway. This gene encodes a member of the receptor-interacting protein(RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminalcaspase recruitment domain(CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator ofNF-kappa Band inducer of apoptosis in response to various stimuli, CARDIAK(CARD-containing ICE-associated kinase) specifically interacted with the CARD of ICE/caspase-1, and this interaction correlated with the processing of pro-caspase-1 and the formation of the active caspase-1 p20 subunit.

Gene Full Name: receptor interacting serine/threonine kinase 2

ID gène: 8767

UniProt: O43353

Pathways: TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades