ROCK2 anticorps (AA 652-923) (FITC)

N° du produit ABIN8032221

L’anticorps anti-ROCK2 Polyclonal Lapin est utilisé pour la détection de ROCK2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour FACS.

Aperçu rapide pour ROCK2 anticorps (AA 652-923) (FITC) (ABIN8032221)

Antigène: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROCK2 est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-ROCK2 anticorps (FITC)

Épitope: AA 652-923

Fonction: Anti-ROCK2 Antibody FITC Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins.

Homologie: Human ROCK2 shares 94.9%,95.2% amino acid (aa) sequence identity with mouse,rat ROCK2,respectively.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ROCK2 recombinant protein (Position: E652-D923). Human ROCK2 shares 94.9% and 95.2% amino acid (aa) sequence identity with mouse and rat ROCK2, respectively.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ROCK2

Antigène: ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))

Autre désignation: ROCK2

Sujet:

Background: Rho-associated kinase (ROCK), including the ROCK-I and ROCK-II isoforms, is a protein kinase involved in signaling from Rho to actin cytoskeleton. Serine/threonine kinase ROCK II/Rho kinase, which is an isozyme of ROCK I, is one of the targets for the small GTPase Rho. ROCK II regulates the formation of actin stress fibers and focal adhesions, cytokinesis, smooth muscle contraction, and the activation of c-fos serum response element. Sequencing analysis has shown that human ROCK II contains 1388 amino acid residues with a calculated molecular mass of approximately 161 kDa. Fluorescence in situ hybridization analysis showed that the human ROCK II gene is located on chromosome 2p24. Thumkeo et al. concluded that ROCK-II is essential in inhibiting blood coagulation and maintaining blood flow in the endothelium-free labyrinth layer and that loss of ROCK-II leads to thrombus formation, placental dysfunction, intrauterine growth retardation, and fetal death.

Gene Full Name: Rho associated coiled-coil containing protein kinase 2

Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

ID gène: 9475

UniProt: O75116

Pathways: Dynamique des Microtubules, Signalisation WNT, Tube Formation