TIGAR anticorps (AA 1-270) (HRP)

N° du produit ABIN8047628

Cet anticorps Lapin Polyclonal détecte spécifiquement TIGAR dans WB, ELISA et IHC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour TIGAR anticorps (AA 1-270) (HRP) (ABIN8047628)

Antigène: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIGAR est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-TIGAR anticorps (HRP)

Épitope: AA 1-270

Fonction: Anti-TIGAR Antibody HRP Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human TIGAR shares 72.8% amino acid (aa) sequence identity with mouse TIGAR.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human TIGAR recombinant protein (Position: M1-R270). Human TIGAR shares 72.8% amino acid (aa) sequence identity with mouse TIGAR.

Isotype: IgG

Information d'application

Indications d'application: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur TIGAR

Antigène: TIGAR (TP53 induced glycolysis regulatory phosphatase (TIGAR))

Autre désignation: TIGAR

Sujet:

Background: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene Full Name: TP53 induced glycolysis regulatory phosphatase

ID gène: 57103

UniProt: Q9NQ88

Pathways: L'effet Warburg