Phospholamban anticorps (AA 1-35) (Biotin)
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- Antigène Voir toutes Phospholamban (PLN) Anticorps
- Phospholamban (PLN)
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Épitope
- AA 1-35
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Phospholamban est conjugé à/à la Biotin
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Application
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Homologie
- Human,Mouse,Rat,Cow,Pig
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human phospholamban
- Isotype
- IgG
- Top Product
- Discover our top product PLN Anticorps primaire
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- Indications d'application
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IHC-P 1:200-400
IHC-F 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C for 12 months.
- Date de péremption
- 12 months
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- Antigène
- Phospholamban (PLN)
- Autre désignation
- phospholamban (PLN Produits)
- Synonymes
- anticorps LOC100226261, anticorps plb, anticorps cmd1p, anticorps CMD1P, anticorps CMH18, anticorps PLB, anticorps Plb, anticorps Plm, anticorps phospholamban, anticorps PLN, anticorps pln, anticorps Pln
- Sujet
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Synonyms: Cardiac phospholamban, CMD1P, PLB, PLN, PPLA_HUMAN.
Background: The Sarco(endo)plasmic-reticulum (SER) regulatory protein, Phospholamban (PLB), is a small, plasma membrane-associated protein found in the SER of cardiac, smooth and slow-twitch muscle. Believed to assemble into a pentamer, PLB regulates cardiac contractility and Ca2+ affinity for cardiac SER Ca2+ ATPase (SERCA2a). Non-phosphorylated PLB associates with SERCA2a, and inhibits Ca2+ reuptake into the SER. PLB activation occurs when key Serine/Threonine residues in PLB (Ser-10, Ser-16, Thr-17) are phosphorylated by numerous effectors, which include PKC, PKA, PKG, and CaM kinase. Phosphorylation of PLB causes dissociation from SERCA2a and a subsequent increase in the rate of Ca2+ reuptake into the SER, which accelerates ventricular relaxation.
- ID gène
- 5350
- Pathways
- Negative Regulation of Transporter Activity
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