Ficolin 2 anticorps

N° du produit ABIN8065461

L’anticorps anti-Ficolin 2 Monoclonal Souris est utilisé pour la détection de Ficolin 2 dans des échantillons de Humain. Il a été validé pour WB et ELISA.

Aperçu rapide pour Ficolin 2 anticorps (ABIN8065461)

Antigène: Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ficolin 2 est non-conjugé

Application: Western Blotting (WB), ELISA

Classe de qualité: Carrier-free

Clone: 16

Détail du produit anti-Ficolin 2 anticorps

Fonction: Anti-L-Ficolin Antibody

Specificité: ABS 005-16 reacts specifically with L-Ficolin. No cross reactivity is seen with M-Ficolin (Ficolin-1) and H-Ficolin (Ficolin-3).

Homologie: Human

Purification: Protein A or Protein G purified

Immunogène: Purified procaryot expressed recombinant human L-Ficolin and full-length L-Ficolin (Ficolin-2) protein.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur Ficolin 2

Antigène: Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))

Autre désignation: L-Ficolin

Sujet: FCN2, EBP-37, FCNL, P35, ficolin-2, ficolin-2, 37 kDa elastin-binding protein, L-ficolin, collagen/fibrinogen domain-containing protein 2, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), ficolin B, ficolin-beta, serum lectin p35,Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:10679061, PubMed:14707097, PubMed:15804047, PubMed:17215869, PubMed:25344472, PubMed:8576206). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:14707097). Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens (PubMed:14707097, PubMed:17215869, PubMed:25344472, PubMed:8576206). Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect (PubMed:8576206). {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:14707097, ECO:0000269|PubMed:15804047, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:25344472, ECO:0000269|PubMed:8576206}.,FCN2,L-Ficolin (Ficolin-2) is an innate immunity pattern recognition molecule found in human serum. L-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP), such as carbohydrates (GlcNAc), lipoteichoic acid and acetylated groups thereby facilitating phagocytosis and activation of complement through the lectin route using the same serine proteases as mannose-binding lectin (MBL) named MASP ((MBL)-associated serine protease) (1).

Poids moléculaire: 35 kDa

ID gène: 2220

UniProt: Q15485

Pathways: Système du Complément