FCN1 anticorps (AA 95-314)

N° du produit ABIN8065464

L’anticorps anti-FCN1 Monoclonal Souris est utilisé pour la détection de FCN1 dans des échantillons de Humain. Il a été validé pour ELISA.

Aperçu rapide pour FCN1 anticorps (AA 95-314) (ABIN8065464)

Antigène: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FCN1 est non-conjugé

Application: ELISA

Classe de qualité: Carrier-free

Clone: 5

Détail du produit anti-FCN1 anticorps

Épitope: AA 95-314

Fonction: Anti-M-Ficolin Antibody

Specificité: ABS 036-05 reacts specifically with M-Ficolin.

Homologie: Human

Purification: Protein A or Protein G purified

Immunogène: Recombinant human M-Ficolin (aa 95 to 314)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur FCN1

Antigène: FCN1 (Ficolin (Collagen/fibrinogen Domain Containing) 1 (FCN1))

Autre désignation: M-Ficolin

Sujet: FCN1, FCNM, ficolin-1, M-ficolin, ficolin (collagen/fibrinogen domain-containing) 1, ficolin-A, ficolin-alpha,Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:16116205, PubMed:17897951, PubMed:20032467). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:16116205, PubMed:20032467). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (PubMed:20032467, PubMed:20400674). May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). {ECO:0000269|PubMed:16116205, ECO:0000269|PubMed:17897951, ECO:0000269|PubMed:20032467, ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}.,FCN1,M-Ficolin (Ficolin-1) is a non-serum protein that is expressed in leukocytes and lung. M-Ficolin precipitates with mannose-binding lectin (MBL)-associated serine proteases (MASP)-1 and MASP-2, indicating that M-Ficolin forms complexes with MASP-1 and MASP-2, recognizes certain types of bacteria and subsequently activates the lectin pathway.

Poids moléculaire: 35 kDa

ID gène: 2219

UniProt: O00602

Pathways: Système du Complément