CGRP anticorps

N° du produit ABIN8065542

L’anticorps anti-CGRP Monoclonal Souris est utilisé pour la détection de CGRP dans des échantillons de Humain. Il a été validé pour ELISA et IHC.

Aperçu rapide pour CGRP anticorps (ABIN8065542)

Antigène: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CGRP est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Classe de qualité: Carrier-free

Clone: 5

Détail du produit anti-CGRP anticorps

Fonction: Anti-Alpha-Calcitonin Gene-Related Peptide (alpha-CGRP) Antibody

Specificité: ABIN8065542 binds human α-CGRP. Based on inhibition ELISA, ABIN8065542 shows full cross-reactivity with rat α-CGRP and about 50 % cross-reactivity with human b-CGRP. There is no cross-reaction with human amylin. The epitope lies within residues 1-18 of human α-CGRP.

Homologie: Human,Rat

Purification: Protein A or Protein G purified

Immunogène: Synthetic human alpha-CGRP

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2-8°C without exposure to light

Date de péremption: 24 months

Détails sur CGRP

Antigène: CGRP (CALCA) (Calcitonin-Related Polypeptide alpha (CALCA))

Autre désignation: Alpha-Calcitonin Gene-Related Peptide

Sujet: CALCA, CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT, KC, PCT, calcitonin, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin 1, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, katacalcin,CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:33602864, ECO:0000269|PubMed:3492492, ECO:0000269|PubMed:38603770, ECO:0000269|PubMed:9620797}.,CALCA,Calcitonin gene-related peptide is a 37 amino acid vasoactive neuropeptide (MW 3789) widely expressed throughout the central and peripheral nervous system. CGRP has potent vasodilatory effects probably serving as a regulator of regional blood flow, In addition to a variety of other cellular effects.

Poids moléculaire: 11 kDa (pro-CGRP), 5 kDa (active)

ID gène: 796

UniProt: P06881

Pathways: Hormone Activity, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development, Feeding Behaviour