E2F1 anticorps (pSer337)

N° du produit ABIN757882

Cet anticorps Lapin Polyclonal détecte spécifiquement E2F1 dans WB, ELISA, IF (p), IF (cc), FACS, IHC (p) et IHC (fro). Il présente une réactivité envers Souris.

Aperçu rapide pour E2F1 anticorps (pSer337) (ABIN757882)

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-E2F1 anticorps

Épitope: pSer337

Réactivité croisée: Souris

Homologie: Human,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human E2F1 around the phosphorylation site of Ser337

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur E2F1

Antigène: E2F1 (E2F Transcription Factor 1 (E2F1))

Autre désignation: E2F1

Sujet:

Synonyms: E2F1Ser337, p-E2F1 Ser337, E2F1 phospho S337, E2F 1, E2F transcription factor 1, E2F-1, E2f1 E2F transcription factor 1, KIAA4009, mKIAA4009, OTTHUMP00000030661, PBR 3, PBR3, PRB binding protein E2F 1, PRB-binding protein E2F-1, RBAP 1, RBAP-1, RBAP1, RBBP 3, RBBP-3, RBBP3, RBP 3, RBP3, Retinoblastoma associated protein 1, Retinoblastoma binding protein 3, Retinoblastoma-associated protein 1, Retinoblastoma-binding protein 3, Transcription factor E2F1, E2F1_HUMAN.

Background: E2F's are DNA binding proteins, which associate with negative regulators, such as the retinoblastoma p107 protein, resulting in an altered rate of gene transcription. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. E2F1 is proposed to be involved in several cellular processes that range from tumor suppressor, cell progression and oncogenesis. E2F1 overexpression can also drive cells into apoptosis.

ID gène: 1869

UniProt: Q01094

Pathways: Signalisation p53, Cycle Cellulaire, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy