BRCA2 anticorps (pSer3291)

N° du produit ABIN8120033

Cet anticorps Lapin Polyclonal détecte spécifiquement BRCA2 dans WB et ELISA. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour BRCA2 anticorps (pSer3291) (ABIN8120033)

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-BRCA2 anticorps

Épitope: pSer3291

Fonction: BRCA2 (phospho Ser3291) Antibody

Specificité: Phospho-BRCA2 (S3291) Polyclonal Antibody detects endogenous levels of BRCA2 protein only when phosphorylated at S3291.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized phospho-peptide around the phosphorylation site of human BRCA2 (phospho Ser3291)

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur BRCA2

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Autre désignation: BRCA2

Sujet:

Synonyms: BRCA2, FACD, FANCD1, Breast cancer type 2 susceptibility protein, Fanconi anemia group D1 protein

Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008],

Gene Name: BRCA2

Protein Name: Breast cancer type 2 susceptibility protein

ID gène: 675

UniProt: P51587

Pathways: Réparation de l'ADN, M Phase, Maintenance of Protein Location