CTNND1 anticorps (AA 600-700)

N° du produit ABIN8120251

Cet anticorps anti-CTNND1 Monoclonal Souris (Clone AB1263) (ABIN8120251) détecte spécifiquement CTNND1 dans IHC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CTNND1 anticorps (AA 600-700) (ABIN8120251)

Antigène: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTNND1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: AB1263

Détail du produit anti-CTNND1 anticorps

Épitope: AA 600-700

Fonction: p120 catenin mouse mAb

Specificité: The antibody can specifically recognize human p120 catenin protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogène: A synthetic peptide corresponding to the amino acid region 600 - 700 of the human p120 catenin protein.

Isotype: IgG

Information d'application

Indications d'application: IHC, 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at-20°C. Avoid freeze / thaw cycles.

Détails sur CTNND1

Antigène: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Autre désignation: p120 catenin

Sujet:

Synonyms: Cadherin associated Src substRate, Cadherin-associated Src substRate, CAS, Catenin (cadherin associated protein) delta 1, Catenin delta 1, Catenin delta, Catenin delta-1, CTND1_HUMAN, CTNND 1, CTNND, CTNND1, delta 1 Catenin, KIAA0384, p120, P120 CAS, p120 catenin, P120 CTN, p120 (cas) , p120 (ctn) , P120CAS, P120CTN

Background: α-Catenin,  β-Catenin,  γ-catenin and p120 catenin are members of the connexin family and mediate intercellular adhesion together with E-cadherin. P120 catenin binds to the near membrane region of E-cadherin to form a complex, which is stable and closely linked. In lobular breast cancer, E-cadherin deficiency resulted in the accumulation of p120 catenin in the cytoplasm, while in ductal breast cancer, p120 catenin in the membrane decreased and there was no accumulation of p120 catenin in the cytoplasm. Therefore, it can be used to distinguish lobular carcinoma from ductal carcinoma. Studies have shown that p120 catenin in the cytoplasm of gastric and colon cancer is related to poor adhesion of cancer cells.

Gene Name: CTNND1

Protein Name: p120 catenin

ID gène: 1500

UniProt: O60716

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling