Cyclin E1 anticorps (pThr62)

N° du produit ABIN8120793

L’anticorps anti-Cyclin E1 Polyclonal Lapin est utilisé pour la détection de Cyclin E1 dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB.

Aperçu rapide pour Cyclin E1 anticorps (pThr62) (ABIN8120793)

Antigène: Cyclin E1 (CCNE1)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin E1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cyclin E1 anticorps

Épitope: pThr62

Fonction: Cyclin E1 (Phospho Thr62) Antibody

Specificité: This antibody detects endogenous levels of Human Cyclin E1 (phospho-Thr62)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized phosho peptide around human Cyclin E1 (Thr62)

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur Cyclin E1

Antigène: Cyclin E1 (CCNE1)

Autre désignation: Cyclin E1

Sujet:

Synonyms: G1/S-specific cyclin-E1

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in

Gene Name: CCNE1 CCNE

Protein Name: Cyclin E1 (Thr62)

ID gène: 898

UniProt: P24864

Pathways: Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases