FGD4 anticorps (AA 291-341)

N° du produit ABIN8121549

L’anticorps anti-FGD4 Polyclonal Lapin est utilisé pour la détection de FGD4 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour FGD4 anticorps (AA 291-341) (ABIN8121549)

Antigène: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGD4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FGD4 anticorps

Épitope: AA 291-341

Fonction: FGD4 Antibody

Specificité: This antibody detects endogenous levels of FGD4 at Human/Mouse/Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human FGD4 AA range: 291-341

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur FGD4

Antigène: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Autre désignation: FGD4

Sujet:

Synonyms: FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament-binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6)

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015],

Gene Name: FGD4 FRABP ZFYVE6

Protein Name: FGD4

ID gène: 121512

UniProt: Q96M96

Pathways: Neurotrophin Signaling Pathway