MKNK2 anticorps (pThr244)

N° du produit ABIN8122767

L’anticorps anti-MKNK2 Polyclonal Lapin est utilisé pour la détection de MKNK2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour MKNK2 anticorps (pThr244) (ABIN8122767)

Antigène: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MKNK2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MKNK2 anticorps

Épitope: pThr244

Fonction: MNK2 (Phospho Thr244) Antibody

Specificité: This antibody detects endogenous levels of MNK2 (Phospho-Thr244) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogène: Synthesized peptide derived from human MNK2 (Phospho-Thr244)

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur MKNK2

Antigène: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Autre désignation: MNK2

Sujet:

Synonyms: MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)

Background: MAP kinase interacting serine/threonine kinase 2(MKNK2) Homo sapiens This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex.

Gene Name: MKNK2 GPRK7 MNK2

Protein Name: MNK2 (Phospho-Thr244)

ID gène: 2872

UniProt: Q9HBH9

Pathways: Signalisation MAPK