MKNK2 anticorps (N-Term)

N° du produit ABIN391072

Détail du produit anti-MKNK2 anticorps

Antigène: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Épitope: AA 70-100, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MKNK2 est non-conjugé

Application: Western Blotting (WB)

Homologie: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MNK2 (MKNK2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-100 amino acids from the N-terminal region of human MNK2 (MKNK2).

Clone: RB5445

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur MKNK2

Antigène: MKNK2 (MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))

Autre désignation: MNK2 (MKNK2) (MKNK2 Produits)

Synonymes: anticorps GPRK7, anticorps MNK2, anticorps gprk7, anticorps mnk2, anticorps 2010016G11Rik, anticorps Gprk7, anticorps Mnk2, anticorps mknk2, anticorps wu:fb37e05, anticorps wz5090, anticorps fi34c11, anticorps wu:fi34c11, anticorps wu:fi41e12, anticorps zgc:55587, anticorps MAP kinase interacting serine/threonine kinase 2, anticorps MAP kinase-interacting serine/threonine kinase 2, anticorps MAP kinase interacting serine/threonine kinase 2b, anticorps MAP kinase interacting serine/threonine kinase 2 L homeolog, anticorps MAP kinase interacting serine/threonine kinase 2a, anticorps MKNK2, anticorps mknk2, anticorps Mknk2, anticorps mknk2b, anticorps mknk2.L, anticorps mknk2a

Sujet: MAP kinase-interacting kinase 1 (Mnk1) and Mnk2, members of the Ser/Thr protein kinase family, bind tightly to the growth factor-regulated MAP kinases, Erk1 and Erk2. Erk and p38 phosphorylate MNK1 and Mnk2, which stimulates their in vitro kinase activity toward a substrate, eukaryotic initiation factor-4E (eIF-4E). Overexpression of Mnk2 results in increased phosphorylation of endogenous eIF-4E, showing that it can act as an eIF-4E kinase in vivo. Mnk2 may play a role in the response to environmental stress and cytokines. This ubiquitiously expressed protein appears to regulate transcription by phosphorylating eIF-4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Expression of active mutants of MNK1 and MNK2 in 293 cells diminishes cap-dependent translation relative to cap-independent translation in a transient reporter assay. Human Mnk2 is homologous to murine Mnk2 (approximately 94 % identical) and human Mnk1 (71 % identical). In vitro phosphorylation studies show that Mnk2 is a significantly better substrate than Mnk1 for extracellular signal-regulated kinase 2 (Erk2), p38MAPKalpha, and p38MAPKbeta. Mnk2 has also been shown to interact with the C-terminal regions of eIF-4G1 and eIF-4G2.

Poids moléculaire: 51875

ID gène: 2872

NCBI Accession: NP_060042, NP_951009

UniProt: Q9HBH9

Pathways: Signalisation MAPK