PEN2 anticorps (AA 51-101)

N° du produit ABIN8123930

Cet anticorps Lapin Polyclonal détecte spécifiquement PEN2 dans IF et IHC. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PEN2 anticorps (AA 51-101) (ABIN8123930)

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PEN2 est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-PEN2 anticorps

Épitope: AA 51-101

Fonction: PEN2 Antibody

Specificité: This antibody detects endogenous levels of PEN2 at Human/Mouse/Rat

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human PEN2 AA range: 51-101

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-200. IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C/1 year

Date de péremption: 12 months

Détails sur PEN2

Antigène: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Autre désignation: PEN2

Sujet:

Background: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease.This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Gene Name: PSENEN PEN2 MDS033

Protein Name: PEN2

ID gène: 55851

UniProt: Q9NZ42

Pathways: Signalisation Notch, Neurotrophin Signaling Pathway