STIM1 anticorps

N° du produit ABIN8124991

Cet anticorps anti-STIM1 Monoclonal Lapin (Clone AB1749) (ABIN8124991) détecte spécifiquement STIM1 dans WB, IHC, ELISA, IF et IP. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour STIM1 anticorps (ABIN8124991)

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp STIM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: AB1749

Détail du produit anti-STIM1 anticorps

Fonction: Stromal Interaction Molecule 1 Rabbit mAb

Specificité: This antibody detects endogenous levels of Stromal Interaction Molecule 1 protein.

Purification: The antibody was purified by protein A affinity chromatography.

Immunogène: Recombinant protein (or fragment).

Isotype: IgG

Information d'application

Indications d'application: WB, 1:1000-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at-20°C. Avoid freeze / thaw cycles.

Détails sur STIM1

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Autre désignation: Stromal Interaction Molecule 1

Sujet:

Synonyms: Stromal interaction molecule 1

Background: This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs) . It is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1) , with the 3' end of this gene situated 1. 6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

Gene Name: STIM1

Protein Name: Stromal Interaction Molecule 1

ID gène: 6786

UniProt: Q13586

Pathways: TCR Signaling, BCR Signaling