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CD28 anticorps

CD28 Reactivité: Humain, Non-Human Primate FACS, WB, IP, IHC (fro), ICC Hôte: Souris Monoclonal CD28-2 unconjugated
N° du produit ABIN775705
  • Antigène Voir toutes CD28 Anticorps
    CD28
    Reactivité
    • 182
    • 141
    • 61
    • 38
    • 21
    • 20
    • 12
    • 12
    • 7
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Non-Human Primate
    Hôte
    • 144
    • 79
    • 39
    • 18
    • 8
    • 3
    • 2
    • 1
    Souris
    Clonalité
    • 214
    • 74
    • 3
    Monoclonal
    Conjugué
    • 97
    • 31
    • 30
    • 22
    • 17
    • 7
    • 7
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    • 6
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD28 est non-conjugé
    Application
    • 214
    • 95
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    • 49
    • 40
    • 31
    • 30
    • 26
    • 20
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    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Specificité
    The mouse monoclonal antibody CD28.2 recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA
    Clone
    CD28-2
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD28 Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 1-12 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Jeong, Qiao, Nascimbeni, Hu, Rehermann, Murthy, Liang: "Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates." dans: Journal of virology, Vol. 78, Issue 13, pp. 6995-7003, (2004) (PubMed).

    Scharschmidt, Wegener, Heissmeyer, Rao, Krappmann: "Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling." dans: Molecular and cellular biology, Vol. 24, Issue 9, pp. 3860-73, (2004) (PubMed).

    Marti, Krause, Post, Lyddane, Dupont, Sadelain, King: "Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 197-206, (2001) (PubMed).

    Galea-Lauri, Darling, Gan, Krivochtchapov, Kuiper, Gäken, Souberbielle, Farzaneh: "Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 1, pp. 62-70, (1999) (PubMed).

    Tazi, Moreau, Bergeron, Dominique, Hance, Soler: "Evidence that Langerhans cells in adult pulmonary Langerhans cell histiocytosis are mature dendritic cells: importance of the cytokine microenvironment." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 6, pp. 3511-5, (1999) (PubMed).

  • Antigène
    CD28
    Autre désignation
    CD28 (CD28 Produits)
    Synonymes
    anticorps Tp44, anticorps CD28RNA, anticorps cd28, anticorps CD28 molecule, anticorps CD28 antigen, anticorps Cd28 molecule, anticorps CD28 molecule L homeolog, anticorps CD28, anticorps Cd28, anticorps cd28.L
    Sujet
    CD28 Molecule,CD28 is the critical T cell costimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its costimulation role CD28 functions in preventing T cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.,TP44
    ID gène
    940
    UniProt
    P10747
    Pathways
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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