COBRA1 anticorps

N° du produit ABIN782439

Détail du produit anti-COBRA1 anticorps

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp COBRA1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~62k COBRA1 protein in Western blots of neonatal Rat brain lysate.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse and Rat.

Purification: Protein G Chromatography of Culture Supernatant.

Immunogène: Recombinant full length Human COBRA1 purified from E. coli.

Clone: F7E4

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Détails sur COBRA1

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Autre désignation: NELF-B (COBRA1 Produits)

Synonymes: anticorps LOC100219583, anticorps COBRA1, anticorps NELF-B, anticorps bZ1O1.4, anticorps cobra1, anticorps cobra2, anticorps fe01e12, anticorps wu:fe01e12, anticorps zgc:55628, anticorps MGC131073, anticorps Cobra1, anticorps RGD1307832, anticorps A730008L03Rik, anticorps AB041607, anticorps AI663983, anticorps Nelf-b, anticorps cofactor of BRCA1, anticorps negative elongation factor complex member B, anticorps negative elongation factor complex member B L homeolog, anticorps LOC100219583, anticorps NELFB, anticorps nelfb, anticorps nelfb.L, anticorps Nelfb

Sujet: COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogeneis (Zhong H et al., 2004).Synonyms: COBRA1, Cofactor of BRCA1, KIAA1182, NELFB, Negative elongation factor B

ID gène: 25920

NCBI Accession: NP_056271

UniProt: Q8WX92