TRIM5 anticorps (C-Term, Isoform gamma)

N° du produit ABIN783538

Cet anticorps Lapin Polyclonal détecte spécifiquement TRIM5 dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour TRIM5 anticorps (C-Term, Isoform gamma) (ABIN783538)

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRIM5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-TRIM5 anticorps

Épitope: C-Term, Isoform gamma

Specificité: This antibody detects TRIM5 / RNF88 (Isoform gamma) at C-term.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acids near the carboxy-terminus of human TRIM5 gamma

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Détails sur TRIM5

Antigène: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Autre désignation: TRIM5 / RNF88

Sujet: TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region (1). TRIM5 has five alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1). While a function has not yet been assigned to TRIM5γ, it is known that expression of TRIM5γ variants from humans, rhesus monkeys, and African green monkeys enable resistance to infection by various retroviruses including HIV-1 (2,3), albeit at differing efficiencies. Furthermore, the TRIM5γ isoform appears to serve as a scaffold for the assembly of endogenous BTBD1 and BTBD2 proteins and also exhibits autoubiquitination activity in a RING finger- and UbcH5B-dependent manner (4).Synonyms: RING finger protein 88, Tripartite motif-containing protein 5

ID gène: 85363

NCBI Accession: NP_149023

UniProt: Q9C035

Pathways: Activation of Innate immune Response