RNF8 anticorps (C-Term)

N° du produit ABIN783604

Cet anticorps Lapin Polyclonal détecte spécifiquement RNF8 dans WB et EIA. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour RNF8 anticorps (C-Term) (ABIN783604)

Antigène: RNF8 (Ring Finger Protein 8 (RNF8))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF8 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-RNF8 anticorps

Épitope: C-Term

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide near the carboxy terminus of human RNF8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur RNF8

Antigène: RNF8 (Ring Finger Protein 8 (RNF8))

Autre désignation: RNF8

Sujet: RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.Synonyms: E3 ubiquitin-protein ligase RNF8, RING finger protein 8

ID gène: 9025

NCBI Accession: NP_003949

UniProt: O76064

Pathways: Production of Molecular Mediator of Immune Response