RNF8 anticorps (C-Term)
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- Antigène Voir toutes RNF8 Anticorps
- RNF8 (Ring Finger Protein 8 (RNF8))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RNF8 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- 14 amino acid peptide near the carboxy terminus of human RNF8
- Top Product
- Discover our top product RNF8 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody (in aliquots) at -20 °C.
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- Antigène
- RNF8 (Ring Finger Protein 8 (RNF8))
- Autre désignation
- RNF8 (RNF8 Produits)
- Synonymes
- anticorps hRNF8, anticorps 3830404E21Rik, anticorps AIP37, anticorps RNF8, anticorps rnf8, anticorps fc66f09, anticorps wu:fc66f09, anticorps zgc:55936, anticorps zgc:77313, anticorps ring finger protein 8, anticorps ring finger protein 8, E3 ubiquitin protein ligase S homeolog, anticorps ring finger protein 8, E3 ubiquitin protein ligase L homeolog, anticorps ring finger protein 8, E3 ubiquitin protein ligase, anticorps RNF8, anticorps Rnf8, anticorps rnf8.S, anticorps rnf8.L, anticorps rnf8
- Sujet
- RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.Synonyms: E3 ubiquitin-protein ligase RNF8, RING finger protein 8
- ID gène
- 9025
- NCBI Accession
- NP_003949
- UniProt
- O76064
- Pathways
- Production of Molecular Mediator of Immune Response
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