ALKBH2 anticorps (C-Term)

N° du produit ABIN783675

Détail du produit anti-ALKBH2 anticorps

Antigène: ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALKBH2 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide near the carboxy terminus of human ALKBH2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur ALKBH2

Antigène: ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))

Autre désignation: ALKBH2 / ABH2 (ALKBH2 Produits)

Synonymes: anticorps si:dkey-65b12.2, anticorps ABH2, anticorps 9530023G02, anticorps AU016977, anticorps Abh2, anticorps mABH2, anticorps RGD1306377, anticorps alkB homolog 2, alpha-ketoglutarate dependent dioxygenase, anticorps alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase, anticorps ALKBH2, anticorps alkbh2, anticorps Alkbh2

Sujet: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA, ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.Synonyms: Alkylated DNA repair protein alkB homolog 2, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, Oxy DC1

ID gène: 121642

NCBI Accession: NP_001001655

UniProt: Q6NS38

Pathways: Réparation de l'ADN