LKB1 anticorps

N° du produit ABIN865492

Cet anticorps Souris Monoclonal détecte spécifiquement LKB1 dans WB, ELISA et FACS. Il présente une réactivité avec des échantillons de Humain, Souris et Singe.

Aperçu rapide pour LKB1 anticorps (ABIN865492)

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivité: Humain, Souris, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LKB1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 4H12

Détail du produit anti-LKB1 anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human STK11 expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: WB: 1/500 - 1/2000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 100g/100l

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur LKB1

Antigène: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Autre désignation: STK11

Sujet: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver. Synonyms: PJS, LKB1, STK11

Poids moléculaire: 54kDa

ID gène: 6794

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg