KIT Ligand anticorps (AA 265-269)
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- Antigène Voir toutes KIT Ligand (KITLG) Anticorps
- KIT Ligand (KITLG)
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Épitope
- AA 265-269
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KIT Ligand est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- The antibody detects endogenous level of total SCF protein.
- Purification
- Affinity purified
- Immunogène
- Peptide sequence around AA 265-269 (E-K-E-R-E) derived from Human SCF. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Top Product
- Discover our top product KITLG Anticorps primaire
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- Indications d'application
- Western blotting: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Antigène
- KIT Ligand (KITLG)
- Autre désignation
- SCF (KITLG Produits)
- Synonymes
- anticorps Xkl-1, anticorps Xsl, anticorps Xsl-1, anticorps Xsl-2, anticorps steel, anticorps KITLG, anticorps SCF, anticorps kitl, anticorps kl-1, anticorps mgf, anticorps scf, anticorps FPH2, anticorps KL-1, anticorps Kitl, anticorps MGF, anticorps SF, anticorps SHEP7, anticorps Clo, anticorps Con, anticorps Gb, anticorps Kitlg, anticorps Mgf, anticorps SLF, anticorps Sl, anticorps blz, anticorps contrasted, anticorps 710-712, anticorps CSF, anticorps KITL, anticorps KIT ligand L homeolog, anticorps KIT ligand, anticorps kit ligand, anticorps kitlg.L, anticorps KITLG, anticorps kitlg, anticorps Kitl, anticorps Kitlg
- Sujet
- Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
- Poids moléculaire
- 25-38 kDa
- ID gène
- 4254
- NCBI Accession
- NP_000890
- UniProt
- P21583
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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