Reticulon 4 anticorps (AA 251-357) (AbBy Fluor® 488)

N° du produit ABIN908635

Cet anticorps Lapin Polyclonal détecte spécifiquement Reticulon 4 dans WB, IF (cc) et IF (p). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Reticulon 4 anticorps (AA 251-357) (AbBy Fluor® 488) (ABIN908635)

Antigène: Reticulon 4 (RTN4)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Reticulon 4 est conjugé à/à la AbBy Fluor® 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Reticulon 4 anticorps (AbBy Fluor® 488)

Épitope: AA 251-357

Specificité: Based on the location of the target sequence this antibody will recognize all isoforms(Nogo-A, Nogo-B, and Nogo-C).

Réactivité croisée: Humain, Souris

Homologie: Rat,Dog,Sheep

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from Mouse Reticulon 4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Reticulon 4

Antigène: Reticulon 4 (RTN4)

Autre désignation: Reticulon 4

Sujet:

Synonyms: Reticulon-4, Rtn4, Neurite outgrowth inhibitor, Nogo protein, Foocen, Neuroendocrine-specific protein, NSP, euroendocrine-specific protein C homolog, RTN-x, Reticulon-5, RTN 4A, Nogo-A, RTN-xL, RTN 4B, ASY, Nogo-B, RTN-xS, Foocen-M, RTN 4C, Nogo-C, Foocen-S, RTN4-B2, Rtn-T

Background: Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The reticulon protein is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Reticulon 4 regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. It regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing.

ID gène: 68585

UniProt: Q99P72

Pathways: Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome