Sortilin 1 anticorps (AA 731-831) (Cy3)

N° du produit ABIN916079

L’anticorps Lapin Polyclonal anti-Sortilin 1 a été validé pour WB, FACS, IF (cc) et IF (p). Il convient pour détecter Sortilin 1 dans des échantillons de Humain, Rat et Souris. Il y a 1 publication disponible.

Aperçu rapide pour Sortilin 1 anticorps (AA 731-831) (Cy3) (ABIN916079)

Antigène: Sortilin 1 (SORT1)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Sortilin 1 est conjugé à/à la Cy3

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Sortilin 1 anticorps (Cy3)

Épitope: AA 731-831

Réactivité croisée: Humain, Souris, Rat

Homologie: Dog,Cow,Pig,Horse,Guinea Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Sortilin

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Sortilin 1 (Cy3) (ABIN916079)

Paik, ONeil, Ng, Sun, Rubin: "Using intracellular markers to identify a novel set of surface markers for live cell purification from a heterogeneous hIPSC culture." dans: Scientific reports, Vol. 8, Issue 1, pp. 804, (2018) (PubMed).

Détails sur Sortilin 1

Antigène: Sortilin 1 (SORT1)

Autre désignation: Sortilin

Sujet:

Synonyms: SORT1,100 kDa NT receptor, Glycoprotein 95 Short name: Gp95, Neurotensin receptor 3 Short name: NT3 Short name: NTR3, SORT_HUMAN

Background: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.

ID gène: 6272

UniProt: Q99523

Pathways: Neurotrophin Signaling Pathway