PCNA anticorps (C-Term)

N° du produit ABIN925999

Cet anticorps Lapin Polyclonal détecte spécifiquement PCNA dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache) et Xenopus laevis.

Aperçu rapide pour PCNA anticorps (C-Term) (ABIN925999)

Antigène: PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Boeuf (Vache), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCNA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PCNA anticorps

Épitope: C-Term

Réactivité croisée: Souris, Rat (Rattus), Chien, Boeuf (Vache), Grenouille, Poisson zebré (Brachydanio rerio)

Immunogène: PCNA antibody was raised in rabbit using the C terminal of PCNA as the immunogen

Information d'application

Indications d'application: WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

PCNA Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this PCNA antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur PCNA

Antigène: PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Autre désignation: PCNA

Sujet: PCNA is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. Synonyms: Polyclonal PCNA antibody, Anti-PCNA antibody, proliferating cell nuclear antigen antibody, MGC8367 antibody.

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy