Cyclin D1 anticorps (Middle Region)

N° du produit ABIN926904

Cet anticorps anti-Cyclin D1 est un anticorps Lapin Polyclonal détectant Cyclin D1 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien, Poisson zèbre (Danio rerio) et Xenopus laevis.

Aperçu rapide pour Cyclin D1 anticorps (Middle Region) (ABIN926904)

Antigène: Cyclin D1 (CCND1)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poulet, Chien, Poisson zèbre (Danio rerio), Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Cyclin D1 anticorps

Épitope: Middle Region

Réactivité croisée: Souris, Rat (Rattus), Chien, Boeuf (Vache), Poisson zebré (Brachydanio rerio), Grenouille, Poulet

Purification: Purified

Immunogène: CCND1 antibody was raised in rabbit using the middle region of CCND1 as the immunogen

Information d'application

Indications d'application: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

CCND1 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this CCND1 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur Cyclin D1

Antigène: Cyclin D1 (CCND1)

Autre désignation: CCND1

Sujet: CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Synonyms: Polyclonal CCND1 antibody, Anti-CCND1 antibody, cyclin D1 antibody, BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody.

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Mitotic G1-G1/S Phases, ER-Nucleus Signaling