PML anticorps (C-Term)

N° du produit ABIN927422

L’anticorps Lapin Polyclonal anti-PML a été validé pour WB. Il convient pour détecter PML dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour PML anticorps (C-Term) (ABIN927422)

Antigène: PML (Promyelocytic Leukemia (PML))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PML est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PML anticorps

Épitope: C-Term

Réactivité croisée: Souris, Rat (Rattus)

Purification: Purified

Immunogène: PML antibody was raised in rabbit using the C terminal of PML as the immunogen

Information d'application

Indications d'application: Optimal conditions should be determined by the investigator.

Commentaires:

PML Blocking Peptide, (ABIN937829), is also available for use as a blocking control in assays to test for specificity of this PML antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur PML

Antigène: PML (Promyelocytic Leukemia (PML))

Autre désignation: PML

Sujet: PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. Synonyms: Polyclonal PML antibody, Anti-PML antibody, promyelocytic leukemia antibody, MYL antibody, PP8675 antibody, RNF71 antibody, TRIM19 antibody.

Pathways: Signalisation p53, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus